To determine which hepatic cell type contributed to alcohol-induced liver diseases by expressing TXNIP, we generated macrophage- or EC-specific Txnip-deficient (TxnipΔMac and TxnipΔEC) mice by crossing Txnipfl/fl mice with LysM-Cre and Tie2-Cre transgenic mice, respectively. The gene discussed is TXNIP; the disease is liver disorder.