Overall, the functional clock can modulate the development and recovery processes of stroke by regulating the daily flux of inflammatory cells between bone marrow, blood, and immune organs; leukocyte numbers in blood show time-of-day-dependent variation which can be abolished by deletion of the core clock gene BMAL1/ARNTL or chronic SCN arrhythmia (Figures 4-5) 45,52. The gene discussed is CLOCK; the disease is stroke disorder.