Mathilde et al.39 found that NRP-1 modulated the 3D invasive properties of glioblastoma stem-like cells, and both RNA interference-mediated silencing and CRISPR-mediated gene editing deletion of NRP-1 strongly impaired the 3D invasive properties of patient-derived cells with stem-like properties and their close localization to brain blood vessels. Here, NRP1 is linked to glioblastoma.