Apparently, our study extended previous observations that the VEGFA/NRP-1 axis is involved in the regulation of tumorigenesis and cancer stemness of breast cancer through GAPVD1, and these findings further broaden the notion that the VEGFA/NRP-1/GAPVD1 axis may be a valuable therapeutic target for the intervention of TNBC. Here, GAPVD1 is linked to breast cancer.