As prior studies have showed that the PI3K/AKT signaling pathway play a role in cell proliferation, differentiation, and glucose metabolism, and is responsible for obesity 42, diabetes 43, and DKD 44, 45, we extracted and imported the gene cluster of the “PI3K/AKT signaling pathway” KEGG term into the Cytoscape for further analysis. The gene discussed is AKT1; the disease is obesity due to melanocortin 4 receptor deficiency.