Filtering for MAM-related proteins 15, 20, we found that the expression of Pacs-2, encoding phosphofurin acidic cluster sorting protein-2, was largely downregulated in diabetic kidneys compared to controls (Figure 3A, Figure S5), suggesting Pacs-2 may be a critical gene mediating the disruption of MAM in DKD. Here, SGCG is linked to diabetic kidney disease.