Females showed a higher early mortality, and female sex was an independent predictor for 30-day mortality. There was no significant difference during follow-up regarding mortality. Differences specific to each sex were observed in the risk factors associated with both early and late mortality, such as elevated preoperative CRP levels were more prevalent among females, whereas culture-negative infective endocarditis was more commonly seen in males. The gene discussed is CRP; the disease is infective endocarditis.