NFE2L2 and steatosis: However, lack of hepatic autophagy in mice was resistant to physiological steatosis due to activation of nuclear factor erythroid 2-related factor 2 (NRF2) and maintenance of nuclear receptor corepressor 1 (NCoR1) 84-86, indicating that compensatory regulations may be upregulated in the organistic system, especially inhibition of fasting-induced de novo lipogenesis in the liver.