CD8A and neoplasm: To eliminate the effects of recipient endogenous ICAM-1 on CD8+ T cells, we isolated CD8+ T cells from WT donor mice bearing MC38 tumors or B16-F10 tumors and intravenously (i.v.)transplanted them into recipient ICAM-1 KO C57BL/6 mice bearing bilateral MC38 tumors, with the primary tumor receiving RT (Figure 4A).