Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis identified alterations in the FoxO signaling pathway associated with cell cycle regulation, the T-cell receptor (TCR) signaling pathway, programmed cell death-ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) checkpoint pathway in cancer (Figure 3C). Here, CD274 is linked to cancer.