To investigate the underlying mechanisms by which VS-6063 upregulates ICAM-1 expression and enhances the systemic antitumor effect of RT in suppressing distant tumors, we compared the tumor immune infiltrates of 4T1 tumor-bearing mice treated with RT alone with those treated with a combination of RT and VS-6063 (Figure 6A). The gene discussed is ICAM1; the disease is neoplasm.