To further investigate whether targeting tumor cell-intrinsic MYC augmented cisplatin therapy, we crossed Mycflox/flox (Mycf/f) mice with keratin 14-Cre/ERT2 mice (K14CreER) to generate K14CreER; Mycflox/flox mice, in which epithelial Myc can be inducibly deleted by tamoxifen treatment. The gene discussed is MAPK3; the disease is neoplasm.