We also observed that the p-IRF3 level was significantly increased in 4NQO induced-HNSCC upon MYCi975 plus cisplatin treatment, confirming that MYCi975 plus cisplatin enhanced the activation the cGAS-STING-IRF3 pathway in vivo. (Figures S9G and S9H). The gene discussed is IRF3; the disease is head and neck squamous cell carcinoma.