Among the epigenetic readers, the bromodomain and extra-terminal (BET) family proteins, which includes Bromodomain Containing 2 (BRD2), Bromodomain Containing 3 (BRD3), Bromodomain Containing 4 (BRD4) and Bromodomain testis-specific protein (BRDT), have been shown to be promising therapeutic targets in multiple types of cancer 11, 12. The gene discussed is BRD3; the disease is cancer.