NLRP3 and familial dilated cardiomyopathy: Intriguingly, hyperglycemia-induced reactive oxygen species (ROS) overproduction may promote the activation of nucleotide-binding oligomerization domain-like receptor (NLR) pyrin domain containing 3 (NLRP3) inflammasome which regulates the death of cardiomyocytes and activation of fibroblasts in DCM 7, 8.