SIRT5 and familial dilated cardiomyopathy: There was no significant difference in heart weight/tibia length (HW/TL) between control and KO mice, indicating that SIRT5 KO did not cause spontaneous cardiac hypertrophy, whereas DCM modeling significantly increased HW/TL values and SIRT5 KO mice demonstrated more severe cardiac hypertrophy (Fig. S1C).