SPI1 and familial dilated cardiomyopathy: AAV-SPI1 treatment rescued the decrease in heart rate in DCM mice (Fig. S1G), and increased +dP/dtmax and E/A and decreased -dP/dtmin and E/e' (Fig. S1H), while AAV-shSIRT5 treatment resulted in loss of the cardioprotective effect of AAV-SPI1 (Fig. S1G-S1H).