Gr-1 antibody can recognize two antigens Ly6G and Ly6C, which expressed on two distinct subsets of Gr-1+ myeloid cells, polymorphonuclear CD11b+Ly6G+ (PMN-MDSCs) and monocytic CD11b+Ly6C+ (M-MDSCs), both subtypes supporting tumor growth and suppressing antitumor immunity35. Here, ITGAM is linked to neoplasm.