In addition, STING, a positive regulator of anti-tumor immune responses, is known to activate TNFR1 and IFNAR1 signaling pathways, resulting in ZBP1 and RIPK3/ASC/CASP8 activation and, consequently, MLKL phosphorylation and cell death 127 (Figure 5). Here, RIPK3 is linked to neoplasm.