In a similar study, TNF-α and IFN-γ associated PANoptosis triggered the activation of GSDMD, GSDME, CASP3, CASP7, CASP8, and MLKL, inducing cell death in 13 distinct human cancer cell lines derived from colon and lung cancer, melanoma, and leukemia 10. The gene discussed is CASP3; the disease is cancer.