GSDMA and cancer: Studies show that Gasdermins (GSDMs)-driver pyroptosis also participates in the inflammatory cell death, PANoptosis, which makes a significant sense to the initiation and progression of diseases 52, including tumors, where GSDM genes are highly upregulated and associated with tumor microenvironment (TME) features, prognosis, clinical characteristics, and stemness scores in several cancer types 53.