The authors found that the increased expression of PANoptosis genes ZBP1, ADAR, CASP2, CASP3, CASP4, CASP8, and GSDMD is detrimental in low-grade glioma across multiple survival models, while AIM2, CASP3, CASP4, and TNFRSF10 also negatively influenced kidney renal cell carcinoma. Here, CASP3 is linked to central nervous system cancer.