Approaches that target the extrinsic apoptotic pathway to induce cancer death include the use of DR agonists such as Fas ligand, tumor necrosis factor-alpha (TNFα), TNF-related apoptosis-inducing ligand (TRAIL), Apo2L/TRAIL, and CD95L/FasL 26,36. The gene discussed is TNFSF10; the disease is cancer.