CCL2 and hepatocellular carcinoma: To elucidate the factors governing G-MDSC recruitment in CRNDE-induced HCC, we examined putative G-MDSC-recruiting chemokines, indicating that the expression of Cxcl3, Cxcl1, Cxcl5, and Ccl2 was significantly increased in upregulated Crnde tumor cells (Figure 5A).