TLR3 and hepatocellular carcinoma: Since previous works have revealed that ectopic CRNDE can elevate the protein levels of TLR3 (Figure 6E), we hypothesized that TLR3 stability in HCC cells might be regulated by CRNDE. Using cycloheximide (CHX) to treat CRNDE-overexpressing and control HCC cells for various durations, we determined that the half-life of TLR3 was significantly prolonged in CRNDE-overexpressing HCC cells, indicating that CRNDE strengthened the stability of TLR3 and inhibited its degradation (Figure 6F).