To investigate the functional relevance between NF-κB and CXCL3, we used si-RELA to knockdown p65, and treated HCC cells with the NF-κB inhibitor pyrrolidinedithiocarbamate ammonium (PDTC), observed that the upregulation of CXCL3 secretion levels induced by CRNDE was blocked (Figure 5F, G). This evidence concerns the gene RELA and hepatocellular carcinoma.