In addition, previous studies revealed that COX-2 (encoded by Ptgs2) and PDL1 (encoded by Cd274) could restrict the proliferation and activation of T cells, implying that CRNDE-induced HCC cells not only increased the recruitment of G-MDSCs to impede the infiltration of T cells but also repressed the activation of T cells. The gene discussed is PTGS2; the disease is hepatocellular carcinoma.