This vaccine is formulated with LPX as a vehicle and mRNAs that encode a fixed set of four melanoma-associated antigens (New York oesophageal squamous cell carcinoma 1 (NY-ESO-1), melanoma-associated antigen A3 (MAGE-A3), tyrosinase, and transmembrane phosphatase with tensin homology (TPTE)). This evidence concerns the gene TPTE and melanoma.