Interestingly, early studies found that in some GH adenoma cells, the basic level of IP3 was higher in GSP (-) cells 47, and this part of the tumor had a poor response to somatostatin analogs 48, and the early studies of our group showed that the transformation rate of phosphatidylinositols (PI) in some GH adenomas was higher 49, suggesting that IP3 plays an essential role in GH adenoma cells. Here, GNAS is linked to neoplasm.