We observed that Quinine synergized with SSTA to induce the most tumor shrinkage and tumor growth arrest (Fig. 7d, Fig. S7a) indicated by Ki-67 staining (Fig. S7b), and tumor which over-expression CX36 was larger than vector, and the benefit was counteracted by OCT and Quinine (Fig. S9b). This evidence concerns the gene GJD2 and neoplasm.