Furthermore, the E3 ubiquitin ligase SMUF2 inhibits the invasion and migration of breast cancer mainly in a scaffold protein CNKSR2-dependent manner 18, also suggesting that CNKSR2, as a scaffold protein, participates in RAS-dependent signaling pathways, highlighting that CNSR2 not only is involved in the signal transduction of kinases but also affects the function of ubiquitin ligases. The gene discussed is CNKSR2; the disease is breast carcinoma.