The ICIs that have been licensed or are in clinical research for HCC treatment include the agents targeting the co-inhibitory receptors such as cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) and the agents targeting the ligand of PD-1, programmed death ligand 1 (PD-L1) 18-20. Here, CD274 is linked to hepatocellular carcinoma.