Besides, as a potential way to overcome the inter-patient heterogeneity among HCC patients, several biomarkers combine 2 different factors or even more factors in a nomogram to stratify the patients into more subgroups for prediction, such as CRP level and AFP level, PIVKA-II level and metastasis, ALBI grade and age, ALBI grade and AFP change, and mALBI grade and AFP level. This evidence concerns the gene CRP and hepatocellular carcinoma.