By scanning and examining the transcription factor binding sites as well as the co-expression of transcription factors (TFs) and their putative target genes, we summarized the top 3 TFs from each cluster (Figure 2D) and observed the highly up-regulated NFE2L1 and NFE2L3 expression in cluster C6 as an important regulator of cancer malignancy 17-19. The gene discussed is NFE2L3; the disease is cancer.