In vivo tumorigenicity assay by subcutaneous inoculation of shS100A11 and non-target control (NTC) HCC cells respectively in NOD-SCID mice showed that S100A11 knockdown in both HCC cell lines significantly reduced the tumor incidence (Figure 4F-G), indicating the role of S100A11 in tumor initiation and growth. The gene discussed is S100A11; the disease is hepatocellular carcinoma.