According to the findings, the mRNA expression of ARL-6 was significantly higher in various cancers compared to adjacent normal tissues, including stomach adenocarcinoma (STAD), liver hepatocellular carcinoma (LIHC), kidney chromophobe (KICH), head and neck cancer (HNSC), esophageal carcinoma (ESCA), colon adenocarcinoma (COAD), and cholangiocarcinoma (CHOL). This evidence concerns the gene ARL6 and cholangiocarcinoma.