CTNND1 has been proved by many studies to be closely related to tumor proliferation and metastasis, such as colorectal cancer 73-75, breast cancer 76, 77, gastric cancer 78, liver cancer 79, etc. In addition, CTNND1 drives butyrophilin-like molecule loss and γδ T-cell exclusion, indicating the immuno-suppressive role of CTNND1 In colon cancer 80. Here, CTNND1 is linked to colorectal cancer.