For example, CTNND1+ tumor cells communicated with stromal cells via many ligand-receptor pairs, such as COL1A1_a1b1 complex, which involved in the activation and differentiation of endothelial and fibroblasts 50, 51, suggesting that the accumulation of CTNND1+ tumor cells will be accompanied by the enrichment of stromal cells, leading to the formation of desert TME. The gene discussed is CTNND1; the disease is neoplasm.