TRAF6 and pachyonychia congenita: The overexpression of TLR4, NOD1, and TRAF6 genes, combined with the decreased expression of MyD88-encoding genes in peripheral leukocytes of patients with PC, may be implicated in chronic inflammation and tumor progression via the upregulation of inherent antibacterial responses, including those triggered by lipopolysaccharide (LPS) 80.