To understand the mechanisms contributing to the differential roles of ALDH1A1 and ALDH1A3 in regulating PCa development, we used androgen-sensitive LNCaP cells for siRNA-mediated knockdown of ALDH1A1, ALDH1A3, AR, RARA, RARG, and RXRA genes or treatment with 5x10-5 M of ATRA for 48 h followed by RNA sequencing (RNAseq). The gene discussed is ALDH1A3; the disease is posterior cortical atrophy.