RXRA and metastatic neoplasm: In primary PCa gene expression datasets TCGA (N = 490) and MSKCC (N = 131), all retinoid receptors have a positive mutual correlation, and a weak negative or no correlation with AR. A negative association of RARG with AR increases in metastatic tumors (MSKCC cohort, N = 19), whereas the mutual correlation of RARA with RARG and RXRA decreases, suggesting a distinct role of these retinoid receptors in the metastatic transcriptional network (Figure 5A).