Furthermore, PLK3 has significantly higher expression in bone metastases than in lymph node metastases (Figure 7B), whereas low PLK3 expression upon ALDH1A1 gain is found mainly in lymph node metastases but not in bone marrow metastases (Figure 7C). The gene discussed is ALDH1A1; the disease is metastatic malignant neoplasm in the lymph nodes.