In contrast, ALDH1A3 expression was upregulated in lymph-node metastatic cells (LNCaP) and downregulated in bone metastatic cells (PC3), suggesting that the inhibition of ALDH1A1 could potentially contribute to the previously described anti-tumor effect of bisphosphonates 30 (Figure S3G). The gene discussed is ALDH1A1; the disease is neoplasm.