SLC30A9 and colonic neoplasm: Additionally, ZnT9 is the coactivator of β-catenin-mediated gene transcription,409,410 which serves as the critical event in the Wnt signaling pathway and the development and progression of colon cancer.411 Notably, the binding of ZnT9 and β-catenin can be competitively replaced by KCTD9, a tumor suppress gene which is negatively correlated with the clinical CRC stage, thus substantially inhibiting the transcription of downstream oncogenes, including MYC, CCND1, and MMP7409 (Fig. 7).