IGFBP2 and esophageal squamous cell carcinoma: MT2A, acting as a zinc donor, induces IGFBP2 and inhibits the expression of E-cadherin through a zinc finger protein.454,455 Recombinant IGFBP2 promoted migration and invasiveness of ESCC cells via NF-κB, Akt, and Erk signaling pathways.