It synergistically suppresses the expression of MYC and ZIP10 (two downstream genes of STAT3), which exerts an anti-carcinogenic activity.431 Furthermore, ZIP6/ZIP10 heteromer plays an essential role in zinc-induced mitosis, involving breast cancer proliferation.156,334 Therefore, targeting the ZIP6/ZIP10 heteromer could be a significant approach to inhibit breast cancer invasion. This evidence concerns the gene STAT3 and breast carcinoma.