In order to stabilize pS38Stathmin throughout mitosis, STAT3 serves as an effector of ZIP6/ZIP10 heteromer regulating the expression of both genes.137,157 Zinc levels are often higher in cancer tissues than normal tissues, possibly due to the increased demand for tumor growth.158 In addition to using zinc chelators to inhibit the proliferative growth of cancer tissues,78,159–161 another potential approach is to use ZIP6 or ZIP10-blocking antibodies to hinder mitosis in cancer progression. The gene discussed is STAT3; the disease is cancer.