Besides, ZIP13 expression and subsequent mobilization of zinc from the ER/Golgi are essential for stimulating BMP/TGF-β signaling in connective tissue.173 Overexpression of ZnT2 has resulted in cell cycle shifts, increased apoptosis, and decreased proliferation and invasion capabilities within MDA-MB-231 cells.39 To summarize, being a risk factor for BC, zinc ions are regulated by ZIPs and ZnTs. Here, SLC30A2 is linked to breast cancer.