Interestingly, overexpression of ZnT8 in α cells leads to the inhibition of glucagon secretion, which may hold potential benefits for T2D.239 Researchers have examined the expression of zinc transporters using fluorescent measurements.238 ZIP1 and ZIP14 were found to be the most abundant influx transporters in pancreatic α cells, while ZnT4, ZnT5, and ZnT8 were the dominant efflux transporters. This evidence concerns the gene SLC30A8 and type 2 diabetes mellitus.