SLC39A7 and heart disorder: ZIP7 upregulation, on the other hand, hinders the accumulation of PINK1 and Parkin in mitochondria by increasing zinc outflow to the cytosol, contributing to the genesis of myocardial reperfusion injury by inhibiting mitophagy during reperfusion.477 Consequently, the upregulation of ZIP7 is considered a significant feature of myocardial reperfusion injury and may present a novel therapeutic target for myocardial reperfusion injury and other cardiac diseases caused by oxidative stress or mitochondrial dysfunction.