SLC39A6 and breast cancer: This downregulation of ZIP6 is associated with increased cell viability and reduced E-cadherin expression.327 Hypoxia, which arises due to the aggressive proliferation of tumor cells, has previously been shown to trigger BC cells to undergo EMT, thereby promoting cell survival and malignant progression.328,329 Similarly, the knockdown of ZIP6 blocks the balance of intracellular zinc levels, resulting in more tolerant cells in hypoxic environments.321 Furthermore, some evidence suggests ZIP6 is associated with a more favorable prognosis.