Besides, the transcription factor MTF-1 enhances cellular protection against oxidative stress, as it responds to alterations in the cell’s redox status.286 Specifically, MTF-1 triggers the expression of the Selenoprotein 1 (Sepw1) gene, responsible for encoding an antioxidant GSH-binding protein that effectively scavenges free radicals.45 Furthermore, MTF1 can be activated by Sirt6, providing liver protection against alcohol-related liver disease.282. This evidence concerns the gene MTF1 and liver disorder.