Its role involves dephosphorylating and activating the Cyclin B/cdk1 complex, which subsequently governs the initiation and advancement of mitosis.348 On the other hand, p53 is identified as the substrate related to ATM coping with DNA damage.349 The subsequent induction of CDK inhibitor p21 CIP1/WAF1 transcriptional activity results in a G1-growth arrest.350 Thus, MT2A may serve as a zinc donor and plausibly promote cell cycle progression through the ATM-cdc25A-dependent pathway in BC. Here, CDKN1A is linked to breast cancer.