The mechanism is through activation of the Snail-N-cadherin pathway.583 Similarly, siZIP4 evoked an epithelioid phenotype in NSCLC, reduced the expression of CSC markers, and elevated cisplatin sensitivity.584 In contrast, within high-grade serous ovarian cancer (HGSOC), the overexpression of ZIP4 increased chemoresistance to cisplatin and doxorubicin.585 Mechanistically, ZIP4 is an upstream regulator of NOTCH3, a storable signature of CSC in HGSOC. The gene discussed is SLC39A4; the disease is ovarian serous adenocarcinoma.