E2F4 and gastric cancer: Alarmingly, reduced expression of MT1 or MT2 has been observed in GC, a pattern correlated with worse prognoses.433 There has been an observed decrease in MT2A and myeloid zinc-finger 1 (MZF1) expression in clinical specimens that are undergoing malignant transformation of the stomach.434 Intriguingly, an important role played by zinc accumulation in controlling cancer through autophagy flux has been reported.435 Autophagic degradation of MT1E, MT1M, and MT1X, initiated by E2F4 in GC, leads to an increase in zinc-stored vesicles within autophagosomes.