It has been reported that interstitial space connection between cancer cells and matrix cells might underpin tumor proliferation and chemoresistance.590,591 In the tumor microenvironment of the lung cancer model, the ZIP1+ CAF subgroup is enrichment after chemotherapy and developed potent gapped junctions with tumor cells via up-regulation of the CX43 protein.592 This study described a fascinating zinc recycling procedure. The gene discussed is GJA1; the disease is neoplasm.