In a study on osteosarcoma, the authors found that ZIP10 expression is induced by chemotherapy and that subsequent increased intracellular zinc content activated CREB and promoted ITGA10 expression.589 Notably, ITGA10 predicted poor osteosarcoma survival because it could promote chemoresistance through PI3K/AKT signaling. The gene discussed is CREB1; the disease is osteosarcoma.