A particular study shed light on Zip5, which was found to be down-regulated in pancreatic β-cells of a diabetic mouse model.612 Intriguingly, the study revealed that zinc influx via Zip5 induced Glut2 expression through the activation of Sirt1-mediated Pgc-1α, proposing Zip5 as potential therapeutic target for diabetes-related diseases. Here, SLC39A5 is linked to diabetes mellitus.