TP53 and invasive ductal breast carcinoma: Additionally, MT overexpression is primarily observed in the invasive ductal carcinoma subtype of BC and is associated with p53 inhibition and resistance to apoptosis.122,344 As previously mentioned, apo-MT was able to eliminate zinc from p53, and reduced the subsequent transcriptional activity, yet it was incapable of binding to DNA.251 Moreover, MTs can influence BC growth through cell cycle effects.