HOXB13 and Familial prostate cancer: Regarding the ZnT transporter family, ZnT4 is five times higher in prostate cancer as measured in normal tissues.111 Furthermore, ZnT4, as well as ZnT10, is highly induced by the HOXB13.384 The introduction of exogenous HOXB13 decreases intracellular zinc levels in prostate cancer cells and activates NF-κB signaling, which promotes prostate cancer invasion.