Indeed, E-cadherin performs its function as a calcium-induced TM glycoprotein, with its decreased expression linked to BC metastasis.323,324 Taylor’ research observed a positive association between STAT3 and ZIP6 in breast cancer samples.320 Furthermore, the induction of ZIP6 expression by STAT3 induces the translocation of ZIP6 to the plasma membrane and facilitates zinc influx, which is triggered by N-terminal cleavage.157 Consequently, the zinc influx activates the zinc influx/GSK-3β inhibition/Snail activation/E-cadherin loss pathway, resulting in cell rounding and detachment (Fig. 5). This evidence concerns the gene CDH1 and breast cancer.