In pan-cancer copy number variation (CNV) and mutation analyses from the TCGA database,456 most of the SLC30 and SLC39 family genes demonstrated gene amplification, especially SLC30A8, SLC30A1, SLC30A10, SLC39A1, and SLC39A4. Notably, the gene for SLC30A8 and SLC39A4 amplification was co-occurring in almost all cancer patients. The gene discussed is SLC30A8; the disease is cancer.