ESR1 and cancer: Among the ZIP zinc transporter family, ZIP10 shows the highest similarity to ZIP6, sharing 43.5% sequence identity, which implies that they likely possess comparable roles in the regulation of cell migration.154,333 As an indicator of metastasis and aggressiveness in cancer progression, ZIP10’s clinical relevance extends to its correlation of estrogen receptor ERBB3 and STAT3 among BC cases,320,334,335 like the previously mentioned ZIP6.