Correspondingly, novel evidence shows that another androgen, dihydrotestosterone, can increase migration and invasion via ZIP9-mediated intracellular Gαi/MAPK/MMP9 signaling in bladder cancer.604 Furthermore, bladder cancer progression dependent on ZIP9 could be inhibited by dutasteride, a 5α-reductase inhibitor.605. This evidence concerns the gene MMP9 and urinary bladder cancer.