Alternative splicing is a critical step in generating protein diversity, and its misregulation has been observed in carcinogenesis.414–416 Notably, alternative splicing of ZIP14 was found to be regulated by the Wnt pathway in CRC, most likely through the regulation of SRPK1 and SRSF1417 (Fig. 7). The gene discussed is SLC39A14; the disease is colorectal carcinoma.