ZnT1 and ZnT4 are expressed throughout the senile plaque, whereas ZnT3, ZnT5, and ZnT6 are localized to the periphery of the plaque.560 ZnT10 mRNA expression is significantly decreased in the frontal cortex of patients with AD,561 similar to the case in APP/PS1 mice. The gene discussed is SLC30A3; the disease is Alzheimer disease.