In pan-cancer copy number variation (CNV) and mutation analyses from the TCGA database,456 most of the SLC30 and SLC39 family genes demonstrated gene amplification, especially SLC30A8, SLC30A1, SLC30A10, SLC39A1, and SLC39A4. Notably, the gene for SLC30A8 and SLC39A4 amplification was co-occurring in almost all cancer patients. This evidence concerns the gene SLC39A4 and cancer.