SLC30A3 and Alzheimer disease: Zinc released during neurotransmission was found to bind to amyloid-β peptides, accelerating the assembly of amyloid-β into oligomers that impair synaptic function.551 Multiple studies indicate that ZnT3 is crucial for reducing the risk of AD by facilitating the excretion of neuronal zinc.40,552–555 The expression level of ZnT3 in the cortex has been observed to decline with age in individuals with AD and in healthy individuals.40,556 Additionally, a rare copy number variant of the ZnT3 gene may be involved in the monogenic determination of autosomal dominant early-onset AD.