Additionally, ZnT9 is the coactivator of β-catenin-mediated gene transcription,409,410 which serves as the critical event in the Wnt signaling pathway and the development and progression of colon cancer.411 Notably, the binding of ZnT9 and β-catenin can be competitively replaced by KCTD9, a tumor suppress gene which is negatively correlated with the clinical CRC stage, thus substantially inhibiting the transcription of downstream oncogenes, including MYC, CCND1, and MMP7409 (Fig. 7). The gene discussed is SLC30A9; the disease is malignant colon neoplasm.