This suggests the physiological importance of the ZIP13-C/EBP-β axis in beige adipocyte biogenesis and thermogenesis, and also highlights its potential in obesity treatment.242 Above all, abnormal glucolipid metabolism is not only contributing to the process of diabetes and obesity, but also involved in carcinogenesis,243,244 suggesting the unique function of zinc transporters both in clinical and preclinical investigations. Here, CEBPB is linked to obesity due to melanocortin 4 receptor deficiency.