There is experimental evidence indicating SPINK1’s role in promoting tumor survival in CRC via the suppression of MTs.624 However, contrary studies have emerged, showing DC-SIGNR’s ability to encourage cancer cell metastasis in CRC through the promotion of MTs.625 These opposing findings underscore the intricate interplay between MTs and cellular mechanisms during cancer progression. The gene discussed is SPINK1; the disease is colorectal carcinoma.