Besides, ovarian cancer, the most lethal gynecologic malignancy, exhibits rapid progression and widespread metastases.459 Of note, ZIP13 was found to promote the proliferation, invasion, adhesion, and metastasis of ovarian cancer cells in vitro and in vivo.73 The underlying mechanisms involve intracellular zinc distribution disruption and activation of the Src/FAK pathway, ultimately leading to ovarian cancer metastasis. This evidence concerns the gene PTK2 and ovarian cancer.