It has been reported that zinc potently enhances MT expression and is cytotoxic to cancer cells.421 MT2A expression decreased in colorectal cancer and was linked to the patient’s tumor M stage.422,423 The present research has mechanistically illustrated that MT2A upregulation promoted the expression of phosphorylated MST1, LATS2, and YAP1, which consequently inhibited the Hippo signaling pathway and controlled CRC cell proliferation and liver metastasis.422 However, it is unclear whether the role of MT in controlling the MST1/LATS2/YAP1 signaling pathway depends on its regulation of zinc. This evidence concerns the gene MT2A and colorectal cancer.