All three TGF-β isoforms (TGF-β1, TGF-β2, and TGF-β3) are confirmed to regulate EndMT in diabetic kidney disease (DKD), and the latest research has shown that TFPI2 contributes to diabetic renal fibrosis and EndMT by positively regulating the TGF-β/Smad signaling pathway [36]. This evidence concerns the gene TFPI2 and diabetic kidney disease.