PIGT and breast cancer: PIGT (Phosphatidylinositol Glycan Anchor Biosynthesis Class T) is a subunit of glycosylphosphatidylinositol (GPI) transamidase (GPIT), which facilitates the modification of proteins by GPI [6]. PIGT mutation can cause seizures, facial dysmorphism, and hypotonia [7]. Overexpression of PIGT has been shown to induce tumorigenesis and contribute to invasion in breast cancer [8, 9].