And for the prognostic value of the DNA methylation of CC chemokine receptors 4 CpGs of CCR1, 1 CpG of CCR2, 1 CpG of CCR3, 4 CpGs of CCR4, 2 CpGs of CCR5, 2 CpGs of CCR6, 1 CpG of CCR7, 1 CpG of CCR8, 3 CpGs of CCR9 and 1 CpG of CCR10 were significantly associated with prognosis in GC patients. The gene discussed is CCR7; the disease is gastric cancer.