LDHB and neoplasm: Once inside, lactate is converted into pyruvate by lactate dehydrogenase B (LDHB) and subsequently enters the mitochondrial tricarboxylic acid (TCA) cycle [17]; on the other hand, as a signaling molecule, it can promote tumor cell proliferation and migration, induce tumor cell epithelial–mesenchymal transition and dryness acquisition, promote tumor immune escape, and mediate chemoradiotherapy tolerance [18–22].