These results demonstrated that “CHANDRAN Metastasis DN”, a gene signature representing genes downregulated in metastatic versus nonmetastatic prostate carcinoma, was identified as the top enriched gene set across all gene sets depleted in PCa tumors with ITGA1/ITGA2 loss/del compared to diploid tumors (Figure 1g,h). Here, ITGA2 is linked to posterior cortical atrophy.