Taken together, our transcriptome profiling analysis highlighted activation of the EMT pathway and the associated TGFβ‐signaling pathway as possible cellular transcriptional programs that underlie the potential higher tumorigenic potential of ITGA1/ITGA2 loss/del in PCa patients and the invasive behavior in α1‐/α2‐integrin dual depleted prostate epithelial cells. The gene discussed is TGFB1; the disease is posterior cortical atrophy.