The transcriptional coactivator YAP1 is a common oncogenic factor that promotes proliferation and migration in several cancer types including PCa.[15] Integrins are central regulators of YAP1 that is activated by the Hippo pathway and has been shown to crosstalk with the TGFβ pathway.[16, 17] We therefore analyzed YAP1 expression and subcellular localization in the different RWPE1 variants. Here, TGFB1 is linked to posterior cortical atrophy.