Fibronectin is not only a ligand for αV‐class integrins, but it also sequestrates latent TGFβ complex and is essential for TGFβ activation.[34] Whether an integrin switch from laminin‐(α6β4) and collagen‐binding (α1β1 and α2β1) integrins to RGD‐binding integrins (αV‐class integrins and α5β1) is indeed driving PCa tumorigenesis merits further studies. This evidence concerns the gene TGFB1 and posterior cortical atrophy.