Fibronectin is not only a ligand for αV‐class integrins, but it also sequestrates latent TGFβ complex and is essential for TGFβ activation.[34] Whether an integrin switch from laminin‐(α6β4) and collagen‐binding (α1β1 and α2β1) integrins to RGD‐binding integrins (αV‐class integrins and α5β1) is indeed driving PCa tumorigenesis merits further studies. The gene discussed is LAMB2; the disease is posterior cortical atrophy.