Some cuproptosis genes were significantly differentially expressed in NAFLD patients compared with normal people (NFE2L2, ATP7B, SLC31A1, LIAS, DLD, PDHA1, PDHB, MTF1, DBT), suggesting that these cuproptosis‐related genes play an important role in the development of NAFLD. Here, PDHA1 is linked to metabolic dysfunction-associated steatotic liver disease.