Some cuproptosis genes were significantly differentially expressed in NAFLD patients compared with normal people (NFE2L2, ATP7B, SLC31A1, LIAS, DLD, PDHA1, PDHB, MTF1, DBT), suggesting that these cuproptosis‐related genes play an important role in the development of NAFLD. The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatotic liver disease.