AKT1 and neoplasm: Triptolide also induces autophagic cell death in some tumor types (metastatic lines S2-013, S2-VP10, and Hs766T) associated with inactivation of the protein kinase B (Akt)/mammalian target of rapamycin/p70S6K pathway and upregulation of the extracellular signal-related kinase 1/2 pathway.