Here, we found that administration of scutellarin notably reduced the number of inflammatory cells in BALF and downregulated the concentrations of IgE, Th2 cytokines, eotaxin, and TGF-β1 in ovalbumin-challenged asthmatic mice, suggesting that scutellarin inhibited the ovalbumin-induced airway inflammation in mice. The gene discussed is TGFB1; the disease is inflammatory response.