GSTM1 and sickle cell disease: To evaluate sheep as a possible animal model for the study of sickle cell disease—a molecular disease resulting from a single β-Glu6Val amino acid substitution in hemoglobin (Hb) in humans—we performed 2 μs MD simulations on the normal human and sheep variants of Hb (huHbA and shHbB) and the sickle forms (huHbS and shHbS), the longest MD simulations to date of any hemoglobin, to our knowledge.