HBB and Schnyder corneal dystrophy: Prior to undertaking the creation of this new SCD model, we herein conducted molecular dynamics (MD) simulations with a modeled structure of the mutant shHbS to characterize the interactions between the β-globin chains and compare them to huHbS to predict if the introduction of the SCD mutation into the sheep HBB gene would result in Hb polymerization and RBC sickling in vivo.