We created a signature of 13 DSP-associated genes (POU4F1, KIF7, DPP7, NECAB2, MAP2, ASB6, TFAP2C, ZNF160, JDP2, FAM219B, GDI1, GPC1, and SLC35G2) and found that it can predict OS in patients with CRC. This evidence concerns the gene POU4F1 and colorectal carcinoma.