To assess the translational relevance of our findings, we examined [18F]FSPG retention in mice bearing orthotopically grown NRF2-high and NRF2-low NSCLC tumours, in the KrasG12D/+; p53flox/flox adenocarcinoma model with and without Nrf2D29H mutations, and in patient-derived human xenografts. Here, NFE2L2 is linked to neoplasm.