MEG3 and lung carcinoma: Notwithstanding additional heterogeneity including a Lyz1+ population in the control lung and a Meg3+ population in the mutant, possibly related to lung cancer and fibrosis12,13, the most prominent change was downregulation of AT2 genes in Cebpa- mutant AT2 cells, without activating progenitor genes or forming a proliferative population as in the neonatal lungs (Fig. 5C).