On this basis, we expressed human UBE2B (homologous to Ubc6, DIOPT homology score=13) and human UBE2D2 and UBE2D4 (homologous to eff, DIOPT scores of 13 and 10, respectively) and compared their capacity to rescue retinal degeneration compared to mock mcherry overexpression (Fig. 2A). Here, UBE2B is linked to retinal degeneration.