TAGLN2 and cancer: In the ascites of mice with metastatic ID8-Defb29/Vegfa OvCa, effector (CD62LlowCD44high) and central memory (CD62LhighCD44high) CD8+ T cells demonstrated a marked reduction in TAGLN2 expression, compared with the same T cell subsets in peritoneal lavage from cancer-free mice (Fig. 3f).