found that DJ-1 can not only induce EMT transcription factor (TF) to activate the epithelial-mesenchymal transition (EMT) program through the TrkC/DJ-1/STAT3 signaling pathway, but also obtain anticancer drug resistance through TrkC-mediated inhibition of DJ-1 degradation30, and studies and other studies have shown that DJ-1 also receives the regulation of different miRNAs upstream in the form of target genes, which has an impact on tumor growth and drug sensitivity XL31. The gene discussed is STAT3; the disease is neoplasm.