It's worth noting that the expression level of DJ-1 in HCC has been linked to survival time, according to studies 27–32, and is inversely correlated with the tumor suppressor gene PTEN and that it can regulate HCC proliferation, apoptosis, invasion, and metastasis by directly affecting MAPK/AKT or indirectly acting on the PI3K/AKT signaling pathway.The components of these signaling cascades have been targeted for therapeutic intervention. The gene discussed is PTEN; the disease is hepatocellular carcinoma.