TargetScan predictive analysis found 157 miRNAs targeting the DJ-1 gene; Then, after superimposing the two databases by Wayne diagram, the HCC diagnostic ROC curve of the TCGA database was analyzed again to determine miR-199a/b-3p as a possible upstream miRNA of the DJ-1 gene for in-depth study. This evidence concerns the gene PARK7 and hepatocellular carcinoma.