Guo XL et al. have shown that DJ-1 regulates PI3K/AKT signaling pathway is closely related to tumor apoptosis and invasion31, while oncogene Ras protein can synergize with DJ-1 gene and act together on PI3K/AKT pathway, and the role of activated Ras, AKT on the imbalance of PI3K/AKT signaling pathway in the pathogenesis of various tumors and the components of its signaling cascade have been gradually demonstrated as therapeutic targets for liver cancer. This evidence concerns the gene AKT1 and liver cancer.