The expression of DJ-1 gene can not only be used as a marker for mental cognitive diseases (such as Parkinson's disease, Alzheimer's disease12,13), but also participate in the occurrence and progression of various tumors (thyroid cancer20, ovarian cancer41, colon cancer14,16,21, liver cancer25–31, lung cancer22,23, renal clear cell carcinoma42, breast cancer17). Here, PARK7 is linked to Parkinson disease.