In summary, our study suggests that miR-199a/b-3p, as an upstream regulatory molecule of DJ-1, may inhibit cell proliferation and invasion of HCC and promote cell apoptosis through a novel compensatory signaling pathway involving miR-199a/b-3p\DJ-1\Ras\PI3K/AKT. The gene discussed is PARK7; the disease is hepatocellular carcinoma.