PARK7 and neoplasm: Guo XL et al. have shown that DJ-1 regulates PI3K/AKT signaling pathway is closely related to tumor apoptosis and invasion31, while oncogene Ras protein can synergize with DJ-1 gene and act together on PI3K/AKT pathway, and the role of activated Ras, AKT on the imbalance of PI3K/AKT signaling pathway in the pathogenesis of various tumors and the components of its signaling cascade have been gradually demonstrated as therapeutic targets for liver cancer.