A large number of studies have shown that miR-199a/b-3p is a tumor suppressor gene, which can inhibit the proliferation, invasion and drug resistance of tumor cells such as gastric cancer32, HCC33–37, breast cancer38, colorectal cancer39 and other tumor cells by regulating PAK4/MEK/ERK, PAK4/BCAR3 and other signaling pathways55,56. Here, PAK4 is linked to neoplasm.