The expression levels of DJ-1 mRNA in TNM stage III and IV HCC tissues ,with vascular invasion ,and pathological grading of 3 and 4 were higher than those in TNM stage I and II tissues(P < 0.01), without vascular invasion, and grading of 1 and 2(P < 0.05). The gene discussed is PARK7; the disease is hepatocellular carcinoma.