To examine whether epithelial-derived MMPs are involved in epithelial remodeling in airway mucosa, we used mucosa from nasal polyps to evaluate the expression levels of MMP7, MMP9, MMP10, and MMP13 in normal epithelium (from control subjects) versus epithelium with goblet cell hyperplasia (from CRS patients). This evidence concerns the gene MMP10 and congenital rubella syndrome.