ACE2 and lung adenocarcinoma: Moreover, we perturbed expression of the top 5 candidates in two additional human cell lines: H2023-AC (a lung adenocarcinoma cell line with ectopically expressed ACE2 and Cas9; Supplementary Fig. 7a) and Calu-3-Cas9 cells (a lung adenocarcinoma line with endogenously expressed ACE2 and ectopically expressed Cas9; Supplementary Fig. 7b).