Interestingly, the TML was significantly different between Pure-LCC and ADLike-LCC (median 5.1 vs. 1.4 muts/Mb; p = 0.04),and the amplification of CRKL and/or MYB was restricted to the Pure-LCC subtype, occurring in 45.5% (5/11) of cases. The gene discussed is CRKL; the disease is leukoencephalopathy with calcifications and cysts.