The DE analysis identified 4 ADLike-LCC specific overexpressed genes: AIM2, DKK1, S100A8, and SERPINB4. Immunohistochemical analysis for Aim2 confirmed its expression in at least 60% of neoplastic cells of all five ADLike-LCC cases but only 3 of the 11 Pure-LCC samples (Supplementary Fig. 3A, Supplementary Table 1). Here, DKK1 is linked to leukoencephalopathy with calcifications and cysts.