In contrast, the transcriptomic analysis of ADLike-LCC showed a distinctive overexpression of NAPSA and Surfactant family genes, typical of adenocarcinomas, together with the exclusive overexpression of AIM2, DKK1, S100A8, and SERPINB4. NAPSA overexpression was associated with the immunopositivity of NapsinA in normal lung tissue within hyperplastic pneumocytes and intra-alveolar macrophages, as previously described [13]. This evidence concerns the gene SERPINB4 and adenocarcinoma.