MAPT and Alzheimer disease: This is supported by data showing that (i) Aβ accelerates tau phosphorylation and aggregation, (ii) complexes of Aβ bound to tau are detected in AD brain extracts, (iii) Aβ core region can bind directly to tau and (iv) Aβ aggregates can trigger/propagate tau pathology in cultured cells and animal models12–15.