Also, FPNI treatment prevented the upregulation of senescence markers that are well-known to be associated to lung fibrosis, such as TNF-α (Fig. 2d), Il6 (Fig. 2e), Cdkn1a (Fig. 2f) and Cdkn1b (Fig. 2g) along with that of collagen isoforms Col1a1 (Fig. 2h) and Col3a1 (Fig. 2i). The gene discussed is TNF; the disease is pulmonary fibrosis.