To verify the putative relevance of PLET1 in the context of human disease, we quantified PLET1 levels in BALF of patients with IAV-induced ARDS compared to a control group of patients with non-inflammatory/non-infectious lung disease (patient characteristics provided in Supplementary Table), and detected high levels in a subset of IAV-ARDS patients (Fig. 7a). This evidence concerns the gene PLET1 and acute respiratory distress syndrome.