We found that vaccination with the CD8-restricted OVA peptide, led to infiltration of endogenous CD8 T cells, but not CD4 T cells or Tregs, in both B16F10 (Fig. 5b) and KPC3-TRP1 (Fig. 5c) tumor models, independent of CD3 bsAb administration (Fig. 5b). This evidence concerns the gene CD4 and neoplasm.