TMIGD2 and acute myeloid leukemia: THP-1 cells overexpressing TMIGD2-FL were more resistant to 666-15-induced apoptosis than cells overexpressing either TMIGD2-dEC or TMIGD2-dIC (Fig. 6h and Supplementary Fig. 6i), indicating that both EC and IC domains of TMIGD2 are important for its function in AML.