TMIGD2 and acute myeloid leukemia: THP-1 cells harboring TMIGD2-Y192F and TMIGD2-S220A showed higher percentage of live cells than TMIGD2-dIC and TMIGD2-Y222F after 666-15 treatment, suggesting that tyrosine 222 is involved in TMIGD2-mediated downstream signaling pathways in AML (Supplementary Fig. 6j).