When treated with 17C7 and 20F2, TMIGD2+ primary AML samples showed significant decrease in colony-forming ability; however, normal HSPCs from CBU and adult BM, as well as TMIGD2- primary AML cells exhibited no significant difference (Fig. 7a, b and Supplementary Fig. 7d), suggesting that anti-TMIGD2 mAbs selectively inhibit TMIGD2+ primary AML cells. This evidence concerns the gene TMIGD2 and acute myeloid leukemia.