Mutations were found in multiple human lung adenocarcinoma (LUAD) related (cancer) genes, including Kras23, Nras24, Csmd325, Dcc25, Epha326, Arid1b27, Arid23, Ptprc24, Ptprd28, Akap928, Setd229, and Pask29 (see Supplementary Table S4 online), while we did not find mutations in typical lung squamous cell carcinoma (LUSC) related genes, such as Mll2, Nfel2, Pik3ca, and Pten3, suggesting that LLC is a lung cancer similar to human LUAD. The gene discussed is PIK3CA; the disease is cancer.