These six LR interactions, namely APOE-SORL1, APOE-LRP1, CALM1-CACNA1C, CALM1-RYR2, CALM3-CACNA1C, and CALM3-RYR2 (Fig. 4c, d), consistently exhibited downregulation patterns in AD in comparative intercellular communication analysis. Here, SORL1 is linked to Alzheimer disease.