In addition, LR pairs containing APOE (APOE-LRP1 and APOE-SORL1) were found to be involved in the top GO terms significantly associated with AD in our pathway analyses, such as “GO CC: endocytic vesicle” and “GO BP: regulation of amyloid precursor protein catabolic process” (Fig. 4a, b). This evidence concerns the gene APP and Alzheimer disease.