As regards genes linked to familial and non-familial forms of PD, including PARK2 (encoding for Parkin) and LRRK2 (encoding for Leucine-rich repeats kinase 2, LRRK2), the interplay between changes in acetylation of α-tubulin and functional defects in axonal transport is evident48,76. The gene discussed is PRKN; the disease is Parkinson disease.