We observed a positive correlation between cGAS-STING scores and tumor mutational burden (TMB, r = 0.254, P < 0.001), homologous recombination deficiency (HRD, r = 0.296, P < 0.001) and intratumor heterogeneity in the TCGA cohort (r = 0.28, P < 0.001) (Fig. 4c, e, Supplementary Fig. 4i). This evidence concerns the gene CGAS and neoplasm.